Defend

Very high sun protection

Defend is a photoprotector suitable for everyday use. Ideal for dry hyper-reactive skin, photodermatosis, photosensitivity due to certain drugs, pigment spots, premature skin aging and immunological alterations. Helps prevent dermatological disordes caused by excess UVB and UVA (SPF 50+) radiation, including solar allergies, stains, elastosis, premature aging and the consequences of the cumulative effect of radiation in the skin.

The tolerability and effectiveness of Defend is tested under dermatological control.

Defend is a multifunctional product. Besides the presence of effective sunscreens against UVB and UVA rays, the formula has been enriched with precious active ingredients, suitable to guarantee:

• Protection against UV rays
• Moisturization
• Soothing
• ALOE VERA

The renowned Aloe Vera or Aloe barbadensis has been scientifically tested for all forms of burn, whether radiant, thermal or solar. It has also been shown to have a prophylactic effect when used before, during and after these skin-damaging events.

Many of the benefits of AV can be attributed to the polysaccharides contained in the leaf gel. However, many other natural chemical constituents of Aloe Vera extract have been associated with its beneficial health effects: amino acids, anthraquinones, enzymes, organic and inorganic compounds, lipids, carbohydrates, lignin, salicylic acid, saponins, sterols and vitamins ( B1, B2, B6, C, β-carotene, choline, folic acid and α–tocopherol).

SYN®-AKE
SYN®-AKE is based on a patented mechanism. It mimics the essential amino acid sequence of the Waglerin-1 functionality. SYN®-AKE‘s safety and activity has been thoroughly tested.

Its effect focuses on an immediate and lasting relaxation of mimicry wrinkles by blocking the neuronal transmission on the NicotinicAcetyhlcholin receptor. The peptide is an antagonist of the muscular nicotinic acetylcholine membrane’s receptor (mnAChR). As themuscular nicotinic Ach receptors are blocked, the ion channel remains closed. There is no uptake of Na+ and the muscle cells stay relaxed. The transmission of nerve impulses to the muscles is inhibited and facial muscles are relaxed.

The efficacy of the SYN®-AKE tripeptide (0.5 mM) has been demonstrated in vitro by measuring the frequency of contraction of the innervated muscle cells as a function of the incubation time.

Results:

• Reduces muscle cell contraction significantly
• Fast-acting
• Long-lasting
• Fully reversible

The measurement of the smoothing and anti-wrinkle effect of SYN®-AKE was compared to a placebo. A cream was applied to the forehead twice daily for 28 days. The study included 15 volunteers per group (age 40–60).

Results:

• Up to 52% wrinkle reduction after 28 days
• Measurable smoothing effect on 80% of the volunteers
• Measurable wrinkle reduction on 73% of the volunteers

ACID Low Molecular Weight (5-10 kDa)

Hyaluronic acid, and, more generally, Mucopolysaccharides, are among the main constituents of connective tissue structures.

The very low molecular weight (5-10 kDA) of hyaluronic acid present in DEFEND, improves intradermal penetration, also constituting a raw material for the formation of medium molecular weight hyaluronic acid.

This type of hyaluronic acid is particularly suitable for retaining water, both in connective tissue and in the fundamental layer of the dermis (and therefore responsible for deep hydration), and in the upper layers of the skin, reducing transepidermal water loss (TEWL ).

COLLOIDAL OATMEAL
Colloidal oatmeal has been used for thousands of years to treat dermatological diseases. Colloidal oatmeal is appreciated for its moisturizing, purifying, antioxidant and anti-inflammatory properties, which are conferred by its chemical heterogeneity.

It has been shown that oatmeal extract inhibits the activity of the nuclear factor Kappa B (NF-kappa B) in keratinocytes and the release of proinflammatory histamine of cytokines. It also modulates the arachidonic acid, the cytosolic phospholipase A2 and the tumor necrosis factor-alpha (TNF-alpha). Colloidal oatmeal has proven to be a safe and effective ingredient in a variety of personal care products.

Contains a variety of active components including polysaccharides, proteins, lipids, saponins, enzymes, flavonoids, vitamins and avenantramides (polyphenols).

A total of 47 subjects completed the clinical efficacy study of a body cream containing oatmeal. This study showed that the skin’s hydration was significantly higher at all times, even 2 weeks after cessation of application, compared to baseline.

The surface area of ​​dead epithelial cells and the epithelial desquamation index on the forearm were significantly reduced at all assessment times compared to baseline.